Most students enrolled in Notre Dame for four years graduate with 27–28 credits.

In addition to the College Preparatory curriculum, Advanced Placement courses are offered for students seeking college credit for their high school work. Dual enrollment courses in which students receive both high school and college credit are also offered. These courses are taught on and off campus by faculty from Chattanooga State Technical Community College.

The school year is divided into four nine-week grading periods covering a time span of two semesters. Students normally take seven classes each semester, and some students gain additional credit through independent study, university-sponsored correspondence courses, and college courses taken in the late afternoon and evening at local colleges and universities. The school day for students begins at 8:10 and ends at 3:10 pm. Students have a daily opportunity for individual assistance from teachers during eighth period, or at other times by appointment.

Notre Dame High School issues a report card at the end of each nine-week term. Parents and students can access online progress reports and other curricular information through their own password protected Edline accounts at anytime. Parent-teacher-student conferences follow the mid-term progress reports and other conferences may be arranged as needed.

Notre Dame High School has a modified block schedule. Classes meet for 90 minutes, five times every two weeks. Every Wednesdays, there is an open period for club and organization activity.